| 000 | 02414nam a2200289Ia 4500 | ||
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| 003 | OSt | ||
| 005 | 20250716122955.0 | ||
| 008 | 220909b |||||||| |||| 00| 0 eng d | ||
| 020 | _a9781584888048 | ||
| 040 |
_aCSL _beng _cCSL |
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| 041 | _aeng | ||
| 084 |
_aB288 Q2 TB _qCSL |
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| 100 |
_a Rothmann, Mark D. _eauthor. _9815742 |
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| 245 | 0 |
_aDesign and Analysis of Non-Inferiority Trials _c/ by Mark D. Rothmann, Brian L. Wiens and Ivan S.F. Chan |
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| 260 |
_aBoca : _bRaton C R C, _c2012. |
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| 300 | _axvi, 438p. | ||
| 490 | _aChapman & Hall/CRC Biostatistics | ||
| 500 | _aIncludes bibliographical references and Index 433-438p. | ||
| 520 | _aThe increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Each chapter begins with a non-technical introduction, making the text easily understood by those without prior knowledge of this type of trial.A variety of issues of non-inferiority trials, including multiple comparisons, missing data, analysis population, the use of safety margins, the internal consistency of non-inferiority inference, the use of surrogate endpoints, trial monitoring, and equivalence trials Specific issues and analysis methods when the data are binary, continuous, and time-to-event The history of non-inferiority trials and the design and conduct considerations for a non-inferiority trial The strength of evidence of an efficacy finding and how to evaluate the effect size of an active control therapy.A comprehensive discussion on the purpose and issues involved with non-inferiority trials, Design and Analysis of Non-inferiority Trials will assist current and future scientists and statisticians on the optimal design of non-inferiority trials and in assessing the quality of non-inferiority comparisons done in practice. | ||
| 650 |
_aDesign and analysis of non-inferiority trials. _9815743 |
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| 650 | _aMathematics. | ||
| 650 | _aStatistics. | ||
| 700 |
_aWiens, Brian L. _eco-author. _9815744 |
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| 700 |
_aChan, Ivan S. F. _eco-author. _9815745 |
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| 942 |
_hB288, Q2 TB _cTEXL _2CC _n0 |
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| 999 |
_c6341 _d6341 |
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